METABOLIC/ SPORADIC
RHEUMATOLOGY/ IMMUNUNOLOGY
APLA SYNDROME
ARTHRALGIA/ STROKE
​
SLE
ARTHRITIS/ PHOTOSENSITIVITY
​
SJOGREN SYNDROME
DRY EYES/ DRY MOUTH
SENSORY NEURONOPATHY
​
CELIAC
DIARRHOEA/ CHOREA
STIMULUS SENSITIVE MYOCLONUS
THYROPEROXIDASE ANTIBODIES
STROKE/ ATAXIA
​
DRUGS
DRUGS (TARDIVE)
LOWER FACE
IMPROVES WITH TALKING/ EATING/ TONGUE OUT
​
VITAMIN DEFICIENCY
VITAMIN B12 DEFICIENCY
RARELY MOVEMENT DISORDER MANIFESTATION
CHOREA/ TREMOR/ MYOCLONUS
PARKINSONISM/ DYSTONIA
​
WERNICKE ENCEPHALOPATHY
ATAXIA/ OPHTHALMOPARESIS/ CONFUSION/ UP-BEAT NYSTAGMUS
​
ELECTROLYTES/ ENDOCRINOLOGY
HYPOCALCAEMIA
PRIMARY HYPOPARATHYROISDIM
CAUSES:
DIGEORGE SYNDROME
AUTOIMMUNE
PTH GENE MUTATION
​
HYPERCALCAEMIA
COGNITION/ CHOREA (RARE)
CAN RARELY MIMIC HUNTINGTON DISEASE
​
HYPOMAGNESEMIA
VERTICAL NYSTAGMUS
ATAXIA
​
HYPERTHYROIDISM
​
HYPERGLYCEMIA (NON-KETOTIC)
​
INFECTIONS/ POST INFECTIOUS
HIV
​
SYDENHAM CHOREA
HYPERACTIVITY/ ADHD
CHOREA/ HYPOTONIA
VOCAL TICS/ CARDITIS
MIGRATING POLYARTHRALGIA
LATENCY BETWEEN GROUP A BETA HEMOLYTIC
STREOTOCOCCAL PHARYNGITIS AND CHOREA
COULD BE FEW MONTHS
LAB: ANTI-DNASE-B TITRE (ELEVATED FOR 1 YEAR)
ASO TITRE
CARDIAC 2D ECHO/ ECG
RX: SODIUM VALPROATE
RISPERIDONE/ TETRABENAZINE
​
OTHERS
PCV (JAK2)
LATE ONSET
MILD GENERALIZED CHOREA
EXECUTIVE DYSFUNCTION
LAB: INCREASED HAEMOGLOBIN LEVEL
RX: HYDROXYUREA
​
SENILE CHOREA
SPORADIC LATE ONSET CHOREA
ETIOLOGIES:
DRUGS/ GENETIC/ AUTOIMMUNE
METABOLIC/ INFECTIONS
​
STROKE
BASAL GANGLIA
​
PHENYTOIN
NORMAL/ HIGH LEVEL
​
AUTOIMMUNE
​
SYDENHAM CHOREA
HYPERACTIVITY/ ADHD
CHOREA/ HYPOTONIA
VOCAL TICS
CARDITIS/ ARTHRITIS
LATENCY BETWEEN GROUP A BETA HEMOLYTIC
STREOTOCOCCAL PHARYNGITIS AND CHOREA
COULD BE FEW MONTHS
LAB: ANTI-DNASE-B TITRE (ELEVATED FOR 1 YEAR)
ASO TITRE
CARDIAC 2D ECHO/ ECG
RX: SODIUM VALPROATE
RISPERIDONE/ TETRABENAZINE
​
NMDA AB
MUTISM/ AUTONOMIC DYSFUNCTION
CENTRAL HYPOVENTILATION
STEREOTYPE (PRESENT IN SLEEP)
FACIAL DYSKINESIA
LIMB/TRUNK DYSKINESIA
PSYCHOSIS PRESENTATION
SYDENHAM LIKE PRESENTATION
FEVER/ HEADACHE/ VOMITING
POST HSV/ VZV INFECTION
NEOPLASIA:
OVARY/ BREAST
SMALL CELL LUNG CARCINOMA
​
CV2/CRMP5 AB
PARKINONISM/ ATAXIA/ CHOREA
AUTONOMIC DYSFUNCTION
MSP-P PHENOTYPE
BILATERAL OPTIC NEUROPATHY
SMALL CELL CARCINOMA LUNG
MRI: BASAL GANGLIA HYPERINTENSITY
PERIVENTRICULAR/ INTERNAL CAPSULE HYPERINTENSITY
​
GABA-A RECEPTOR ​
GENERALIZED CHOREA
OROFACIAL CHOREA
CATATONIA
PHENOTYPE MAY BE SIMILAR TO NMDA ENCEPHALITIS
MRI: MULTIFOCAL CORTICAL SUBCORTICAL WHITE MATTER HYPERINTENSITY
​
CASPR2
LOWER LIMB ACTION MYOCLONUS
SEGMENTAL/ PROPRIOSPINAL MYOCLONUS
SMALL CALL CARCINOMA LUNG
THYOMOMA
MRI: BASAL GANGLIA HYPERINTENSITY
​
LG1
FACIOBRACHIAL DYSTONIC SEIZURES
D2R
CHILDHOOD/ PARKINSONISM/ DYSTONIA
​
GAD AB
PHENOTYPE:
ATAXIA/ PARKINSONISM/ PSP
STIFF PERSON SYNDROME
STARTLE MYOCLONUS
OPSOCLONUS-MYOCLONUS
ORTHOSTATIC TREMOR
LIMBIC ENCEPHALITIS/ MTLE
ABNORMAL SACCADES
VELOCITY/LATENCY/ACCURACY
SACCADE INITIATION
EARLY UPGAZE PALSY
NYSTAGMUS
DOWN/ UP BEAT NYSTAGMUS
PERIODIC ALTERNATING NYSTAGMUS
FLUTTER/OPSOCLONUS
STIFF EYES
​
YO/HU AB
ASSOCIATION: SLE/SJOGREN/RA
CARCINOMA LUNG/ HODGKIN/ NON HODGKIN/ GASTRIC/COLON/ PROSTATE/ BLADDER/ BREAST/ PANCREATIC/ OVARY
​
IgLON5 AB
SLEEP PROBLEMS:
OSA/RBD/NREM/ STRIDOR
OCULAR:
SACCADIC INTRUSIONS/ VSGP
SYMPTOMS:
COGNITION/SEIZURES/ENCEPHALOPATHY
PARKINSONISM/DYSTONIA/ATAXIA
OROMANDIBULAR DYSTONIA
OROFACIAL DYSKINESIA
HYPEREKPLEXIA
MYORHYTHMIA/ TREMOR
AUTONOMIC DYSFUNCTION
DIABETES INSIPIDUS/ MYOKYMIA
PHENOTYPES:
CBS/ PSP/MSA/HD/SPS/MND
​
​
PAROXYSMAL DISORDERS​
​
STATIC/ MILD
ADCY5
AGE OF ONSET 1-20YRS
MYOCLONUS/DYSTONIA/CHOREA
CAN BE MILD/ STATIC
AXIAL HYPOTONIA/ FACIAL MYOKYMIA
FROG LIKE GAIT/ OCULOMOTOR APRAXIA
VERTICAL SACCADES ABNORMALITY
DROWSY/ BALLISTIC DYSTONIA (PAINFUL)
RX: CAFFEINE/ ACETAZOLAMIDE
CLONAZEPAM/ DBS
PDE10A
AGE OF ONSET: 5-15YRS
DIURNAL VARIATION
MRI: BASAL GANGLIA HYPERINTENSITY (T2)
​
BENIGN HEREDITARY CHOREA
(NKX2-1/TITF1)
LUNG: OBSTRUCTIVE/ INTERSTITIAL LUNG DISEASE/ RECURRENT INFECTIONS
THYROID: CONGENITAL HYPOTHYROIDISM
BRAIN: CHOREA/ MYOCLONUS/ DYSTONIA/ ATAXIA/ HYPOTONIA
OCD/ ADHD/ PSYCHOSIS
OTHER: WEB NECK/ SHORT STATURE/ JOINT HYPER-MOBILITY
​
PRRT2
SECONDS TO MINS DURATION
LIMBS > NECK OR FACE
BENIGN FAMILIAL INFANTILE EPILEPSY
INFANTILE CONVULSIVE CHORE-
ATHETOSIS (ICCA)
ABSENCE SEIZURE
PAROXYSMAL TORTICOLLIS
EPISODIC ATAXIA/ PED
TRIGGERS:
STARTLE/ HYPERVENTILATION/ EXERCISE
RX: CARBAMAZEPINE
​
MENTAL RETARDATION/ SEIZURES
GNAO1
PAROXYSMAL DYSTONIA/ CHOREA
PKD
MENTAL RETARDATION/ FOCAL SEIZURES
​
GRIN1
MENTAL RETARDATION/ SEIZURES
CHOREA/ DYSTONIA
​
GPR88
AGE OF ONSET 8-10YRS
SPEECH DELAY/ LEARNING DISABILITY
​
GNB1
SIMILAR TO GNAO1
PAROXYSMAL DYSTONIA/ CHOREA
PROLONGED EPISODES
DYSTONIA MYOCLONUS / STEREOTYPE
MICROCEPHALY
​
