AUTOIMMUNE
​
CASPR2 AB
LOWER LIMB ACTION MYOCLONUS
SEGMENTAL/ PROPRIOSPINAL MYOCLONUS
EPISODIC ATAXIA
NEUROMYOTONIA/ MYOKYMIA
SMALL CALL CARCINOMA LUNG
THYOMOMA
MRI: BASAL GANGLIA HYPERINTENSITY
​
GLYCINE RECEPTOR AB
HYPEREKPLEXIA
PERM:
LIMB OR AXIAL PAINFUL SPASMS
RIGIDITY/ NYSTAGUS/ OPSOCLONUS
CORTICAL MYOCLONUS/ STARTLE
DEAFNESS/ OPHTHALMOPARESIS
DYSARTHRIA
APNEA/ HYPERSOMNOLENCE
ASSOCIATED WITH THYMOMA
LAB: CSF PLEOCYTOSIS
LGI1 AB
FACIOBRACHIAL DYSTONIC SEIZURES​
DROP/ ATONIC ATTACKS
HYPONATREMIA
EPISODIC BRADYCARDIA
​
IgLON5 AB
SLEEP PROBLEMS:
OSA/RBD/NREM/ STRIDOR
OCULAR:
SACCADIC INTRUSIONS/ VSGP
SYMPTOMS:
COGNITION/SEIZURES/ENCEPHALOPATHY
PARKINSONISM/DYSTONIA/ATAXIA
OROMANDIBULAR DYSTONIA
OROFACIAL DYSKINESIA
HYPEREKPLEXIA
MYORHYTHMIA/ TREMOR
AUTONOMIC DYSFUNCTION
DIABETES INSIPIDUS/ MYOKYMIA
PHENOTYPES
CBS/ PSP/MSA/HD/SPS/MND
​
​DPPX6 AB
COGNITION
THORACIC STIFFNESS
PARKINSONISM (PSP PHENOTYPE)
BRAIN STEM INVOLVEMENT
GI DYSAUTONOMIA
DIARRHOEA/ WEIGHT LOSS
TREMOR/ MYOCLONUS/ HYPEREKPLEXIA
SEIZURES/ PARKINSONISM/ ATAXIA
GFAP AB
MENINGOENCEPHALOMYELITIS
ATAXIA (30%)
TREMORS(30%)
PSYCHIATRIC(30%)
AUTONOMIC (30%)
MRI: LINEAR PERIVENTRICAL CONTRAST ENHANCEMENT
​
GAD AB
PHENOTYPE
ATAXIA/ PARKINSONISM/ PSP
STIFF PERSON SYNDROME
STARTLE MYOCLONUS/ PERM
HEAD RETRACTION JERK
OPSOCLONUS-MYOCLONUS
ORTHOSTATIC TREMOR
LIMBIC ENCEPHALITIS/ MTLE
ABNORMAL SACCADES
VELOCITY/LATENCY/ACCURACY
SACCADE INITIATION/ EARLY UPGAZE PALSY
NYSTAGMUS
DOWN/ UP BEAT NYSTAGMUS
PERIODIC ALTERNATING NYSTAGMUS
FLUTTER/OPSOCLONUS/ STIFF EYES
>50YRS: 8%+VE GAD POSITIVE
OPSOMYOCLONUS ATAXIA
NEUROBLASTOMA
LAB: URINE VMA/ METANEPHRINE
​
RI AB
AGE OF ONSET >40YRS
SUBACUTE ONSET PARKINSONISM
JAW CLOSING DYSTONIA
PSP PHENOTYPE
OCULOPALATAL-MYOCLONUS
NEOPLASIA: BREAST/ OVARY
​
GAD AB
PHENOTYPE
ATAXIA/ PARKINSONISM/ PSP
STIFF PERSON SYNDROME
STARTLE MYOCLONUS/ PERM
HEAD RETRACTION JERK
OPSOCLONUS-MYOCLONUS
ORTHOSTATIC TREMOR
LIMBIC ENCEPHALITIS/ MTLE
ABNORMAL SACCADES
VELOCITY/LATENCY/ACCURACY
SACCADE INITIATION/ EARLY UPGAZE PALSY
NYSTAGMUS
DOWN/ UP BEAT NYSTAGMUS
PERIODIC ALTERNATING NYSTAGMUS
FLUTTER/OPSOCLONUS/ STIFF EYES
>50YRS: 8%+VE GAD POSITIVE
​
NMDA AB
MUTISM/ AUTONOMIC DYSFUNCTION
CENTRAL HYPOVENTILATION
STEREOTYPE (PRESENT IN SLEEP)
FACE DYSKINESIA
LIMB/TRUNK DYSKINESIA
PSYCHOSIS PRESENTATION
FEVER/ HEADACHE/ VOMITING
POST HSV/ VZV INFECTION
NEOPLASIA: OVARY/ BREAST
SMALL CELL LUNG CARCINOMA
​
GLYCINE-RECEPTOR AB
HYPEREKPLEXIA/ PERM
​
GABA-B RECEPTOR AB
SEIZURES/ MYORHYTHMIA
​
KELCH LIKE (KLH11 AB)
RHOMBENCEPHALITIS
DEAFNESS/VERTIGO
TESTICULAR SEMINOMA
BRAINSTEM/ MTL / DENTATE HYPERINTENSITY
​
POST-INFECTIOUS
​
IDIOPATHIC
PERM
GAD/ GLYCINE-RECEPTOR/ DPPX6 AB
LIMB OR AXIAL PAINFUL SPASMS
RIGIDITY/ NYSTAGUS/ OPSOCLONUS
CORTICAL MYOCLONUS/ STARTLE
DEAFNESS/ OPHTHALMOPARESIS
DYSARTHRIA
APNEA/ HYPERSOMNOLENCE
ASSOCIATED WITH THYMOMA
LAB: CSF PLEOCYTOSIS
CATAPLEXY
MA2 AB
CATAPLEXY
​
CASPR2 AB
LOWER LIMB ACTION MYOCLONUS
SEGMENTAL/ PROPRIOSPINAL MYOCLONUS
SMALL CALL CARCINOMA LUNG
THYMOMA
​
LGI1 AB
FACIOBRACHIAL DYSTONIC SEIZURES​
DROP/ ATONIC ATTACKS
HYPONATREMIA
EPISODIC BRADYCARDIA
​
​
​
​
METABOLIC
DRUGS
ANTIPARKINSONISM
LEVODOPA
BROMOCRIPTINE
AMANTADINE
ANTIDEPRESSANTS
TCA
SSRI
LITHIUM
​
ANXIOLYTICS
BUSPIRONE
BENZODIAZEPINE WITHDRAWAL
​
DOPAMINE BLOCKING AGENTS
ANTIPSYCHOTIC DRUGS
METOCHLOPRAMIDE
​
ANTIEPILEPTICS
CARBAMAZEPINE
PHENYTOIN
GABAPENTINE
LAMOTRIGINE
​
DOPAMINE BLOCKING AGENTS
ANTIPSYCHOTIC DRUGS
METOCHLOPRAMIDE
OPIATE DRUGS
MORPHINE
FENTANYL
METHADONE
ANTI-NEOPLASTIC
CHLORAMBUCIL
IOFDAMIDE
ANTI-INFECTIVE
PENICILLIN
CEPHALOSPORINE
IMEPENEM
PIPERACILLIN
QUINOLONES
ISONIAZIDE
ACYCLOVIR
CARDIOVASCULAR
DILTIAZEM
NIFEDIPINE
GENERAL ANESTHETICS
PROPOFOL
ETOMIDATE
ENFLURANE
​
METABOLIC
RENAL FAILURE
LIVER FAILURE
HYPOXIA
THYROTOXICOSIS
HYPOGLYCAEMIA
NON-KETOTIC HYPERGLYCEMIA
HYPONATRAEMIA
HYPOCALCAEMIA
​
