AUTOIMMUNE PARKINSONISM

​

MA2 AB

VSGP/ RBD

THYMOMA/ TESTICULAR CANCER

APRAXIA EYELID OPENING

MRI: HYPOTHALAMUS PITUITARY DYSFUNCTION

THALAMIC/ HYPOTHALAMIC HYPERINTENSITY

​

RI AB

AGE OF ONSET >40YRS

SUBACUTE ONSET PARKINSONISM

PSP PHENOTYPE

OCULOPALATAL-MYOCLONUS

NEOPLASIA: BREAST/ OVARY

​

IgLON5 AB

SLEEP PROBLEMS:

OSA/RBD/NREM/ STRIDOR

OCULAR:

SACCADIC INTRUSIONS/ VSGP

UPGAZE PALSY, UNLIKE PSP

SYMPTOMS:

COGNITION/SEIZURES/ENCEPHALOPATHY

PARKINSONISM/DYSTONIA/ATAXIA

OROMANDIBULAR DYSTONIA 

OROFACIAL DYSKINESIA

HYPEREKPLEXIA

MYORHYTHMIA/ TREMOR

AUTONOMIC DYSFUNCTION

DIABETES INSIPIDUS/ MYOKYMIA

PHENOTYPES

CBS/ PSP/MSA/HD/SPS/MND

SYMPTOMS

BULBAR 80%

SLEEP 80%

COGNITION 50%

ATAXIA 70%

CHOREA 30%

BRADYKINESIA/ RIGIDITY 30%

DYSTONIA 30%

TREMOR 20%

MYOCLONUS/ MYORHYTHMIA/MYOKYMIA 30%

RX: IMMUNOTHERAPY EFFECTIVE IN 13%

​

​DPPX6 AB

COGNITION

THORACIC STIFFNESS

PARKINSONISM (PSP PHENOTYPE)

BRAIN STEM INVOLVEMENT

GI DYSAUTONOMIA

DIARRHOEA/ WEIGHT LOSS

TREMOR/ MYOCLONUS/ HYPEREKPLEXIA

SEIZURES/ PARKINSONISM/ ATAXIA

​

LGI1 AB

FACIOBRACHIAL DYSTONIC SEIZURES​

DROP/ ATONIC ATTACKS

HYPONATREMIA

EPISODIC BRADYCARDIA

PARKINSONISM (PSP PHENOTYPE)

​

CRMP5 AB

PARKINSONISM/ ATAXIA

AUTONOMIC DYSFUNCTION

MSP-P PHENOTYPE

BILATERAL OPTIC NEUROPATHY

SMALL CELL CARCINOMA LUNG

MRI: HYPERINTENSITY (FLAIR)

BASAL GANGLIA/ PERIVENTRICULAR

INTERNAL CAPSULE 

​

CASPR2 AB

LOWER LIMB ACTION MYOCLONUS

SEGMENTAL/ PROPRIOSPINAL MYOCLONUS

EPISODIC ATAXIA

NEUROMYOTONIA/ MYOKYMIA

SMALL CELL CARCINOMA LUNG

THYMOMA

MRI: BASAL GANGLIA HYPERINTENSITY

​

DOPAMINE RECEPTOR 2 AB

CHILDHOOD PARKINSONISM

​

NMDA AB

MUTISM/ AUTONOMIC DYSFUNCTION

CENTRAL HYPOVENTILATION

STEREOTYPE (PRESENT IN SLEEP)

FACE DYSKINESIA

LIMB AND TRUNK DYSKINESIA

PSYCHIATRIC PRESENTATION

FEVER/ HEADACHE/ VOMITING

POST HSV/ VZV INFECTION

NEOPLASIA: OVARY/ BREAST

SMALL CELL LUNG CARCINOMA

​

GLYCINE-RECEPTOR AB

PARKINSONISM + FTD

STRIATO-LIMBIC ENCEPHALITIS WITH

PARKINSONISM (RARE)

​

ANTI-GLUTAMIC ACID DECARBOXYLASE (GAD) AB

PHENOTYPE:

ATAXIA/ PARKINSONISM/ PSP

STIFF PERSON SYNDROME

STARTLE MYOCLONUS

OPSOCLONUS-MYOCLONUS

ORTHOSTATIC TREMOR

LIMBIC ENCEPHALITIS/ MTLE

ABNORMAL SACCADES

VELOCITY/LATENCY/ACCURACY

SACCADE INITIATION/ EARLY UPGAZE PALSY

NYSTAGMUS

DOWN/ UPBEAT NYSTAGMUS

PERIODIC ALTERNATING NYSTAGMUS

FLUTTER/OPSOCLONUS/ STIFF EYES

IgG INDEX INCREASED

>50YRS: 8%+VE GAD POSITIVE

​

​